6ZVP
Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms
Summary for 6ZVP
Entry DOI | 10.2210/pdb6zvp/pdb |
EMDB information | 11309 11467 |
Descriptor | Tyrosine 3-monooxygenase, FE (III) ION, L-DOPAMINE (3 entities in total) |
Functional Keywords | tetramer, dopamine, catecholamine, brain, parkinson, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 206435.53 |
Authors | Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Valpuesta, J.M.,Martinez, A.,Flydal, M.I. (deposition date: 2020-07-27, release date: 2021-11-17, Last modification date: 2022-02-02) |
Primary citation | Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13:74-74, 2022 Cited by PubMed: 35013193DOI: 10.1038/s41467-021-27657-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
Download full validation report