6ZVP

Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms

6ZVP の概要

• エントリーDOI: 10.2210/pdb6zvp/pdb
• EMDBエントリー: 11309 11467
• 分子名称: Tyrosine 3-monooxygenase, FE (III) ION, L-DOPAMINE (3 entities in total)
• 機能のキーワード: tetramer, dopamine, catecholamine, brain, parkinson, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 206435.53

構造登録者

Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Valpuesta, J.M.,Martinez, A.,Flydal, M.I. (登録日: 2020-07-27, 公開日: 2021-11-17, 最終更新日: 2022-02-02)

• 主引用文献: Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M.; Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation.; Nat Commun, 13:74-74, 2022; PubMed: 35013193; DOI: 10.1038/s41467-021-27657-y

実験手法

ELECTRON MICROSCOPY (4 Å)