6ZU8

Crystal structure of human Brachyury G177D variant in complex with Afatinib

6ZU8 の概要

• エントリーDOI: 10.2210/pdb6zu8/pdb
• 分子名称: Brachyury protein, ZINC ION, N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)butanamide, ... (4 entities in total)
• 機能のキーワード: brachyury, tbxt, afatinib, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22633.76

構造登録者

Newman, J.A.,Gavard, A.E.,Shrestha, L.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O. (登録日: 2020-07-21, 公開日: 2020-08-05, 最終更新日: 2024-01-31)

• 主引用文献: Newman, J.A.,Gavard, A.E.,Shrestha, L.,Burgess-Brown, N.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.,Bountra, C.,Gileadi, O.; Crystal structure of human Brachyury G177D variant in complex with Afatinib; To Be Published,

実験手法

X-RAY DIFFRACTION (1.95 Å)