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6ZTC

CRYSTAL STRUCTURE OF PROSTAGLANDIN D2 SYNTHASE IN COMPLEX WITH FRAGMENT 1A AT 1.84A RESOLUTION.

Summary for 6ZTC
Entry DOI10.2210/pdb6ztc/pdb
DescriptorHematopoietic prostaglandin D synthase, GLUTATHIONE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordsprostaglandin biosynthesis, fatty acid biosynthesis, prostaglandin d2 synthase, pgds, asthma, cytoplasm, isomerase, lipid synthesis
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight48317.61
Authors
Somers, D.O. (deposition date: 2020-07-17, release date: 2021-07-28, Last modification date: 2024-05-01)
Primary citationSchulte, C.A.,Deaton, D.N.,Diaz, E.,Do, Y.,Gampe, R.T.,Guss, J.H.,Hancock, A.P.,Hobbs, H.,Hodgson, S.T.,Holt, J.,Jeune, M.R.,Kahler, K.M.,Kramer, H.F.,Le, J.,Mortenson, P.N.,Musetti, C.,Nolte, R.T.,Orband-Miller, L.A.,Peckham, G.E.,Petrov, K.G.,Pietrak, B.L.,Poole, C.,Price, D.J.,Saxty, G.,Shillings, A.,Smalley Jr., T.L.,Somers, D.O.,Stewart, E.L.,Stuart, J.D.,Thomson, S.A.
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors.
Bioorg.Med.Chem.Lett., 47:128113-128113, 2021
Cited by
PubMed: 33991628
DOI: 10.1016/j.bmcl.2021.128113
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.84 Å)
Structure validation

222036

건을2024-07-03부터공개중

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