6ZS4

Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate

Summary for 6ZS4

Entry DOI	10.2210/pdb6zs4/pdb
Descriptor	Protein polybromo-1, tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bromodomain, complex, small molecule, structural genomics consortium, sgc, transcription, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	15081.50
Authors	Preuss, F.,Joerger, A.C.,Kraemer, A.,Wanior, M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-07-15, release date: 2020-10-07, Last modification date: 2024-01-31)
Primary citation	Wanior, M.,Preuss, F.,Ni, X.,Kramer, A.,Mathea, S.,Gobel, T.,Heidenreich, D.,Simonyi, S.,Kahnt, A.S.,Joerger, A.C.,Knapp, S. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63:14680-14699, 2020 Cited by PubMed: 33216538 DOI: 10.1021/acs.jmedchem.0c01242 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation