6ZS4

Crystal structure of the fifth bromodomain of human protein polybromo-1 in complex with tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate

6ZS4 の概要

• エントリーDOI: 10.2210/pdb6zs4/pdb
• 分子名称: Protein polybromo-1, tert-butyl 4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazine-1-carboxylate, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: bromodomain, complex, small molecule, structural genomics consortium, sgc, transcription, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15081.50

構造登録者

Preuss, F.,Joerger, A.C.,Kraemer, A.,Wanior, M.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-07-15, 公開日: 2020-10-07, 最終更新日: 2024-01-31)

• 主引用文献: Wanior, M.,Preuss, F.,Ni, X.,Kramer, A.,Mathea, S.,Gobel, T.,Heidenreich, D.,Simonyi, S.,Kahnt, A.S.,Joerger, A.C.,Knapp, S.; Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.; J.Med.Chem., 63:14680-14699, 2020; PubMed: 33216538; DOI: 10.1021/acs.jmedchem.0c01242

実験手法

X-RAY DIFFRACTION (2 Å)