6ZS2

Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol

Summary for 6ZS2

• Entry DOI: 10.2210/pdb6zs2/pdb
• Descriptor: Transcription activator BRG1, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, atp-dependent helicase smarca4, brg1-associated factor 190a, baf190a, mitotic growth and transcription activator, protein brg-1, protein brahma homolog 1, snf2-beta, swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a member 4, structural genomics consortium, sgc, transcription, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 29129.68

Authors

Preuss, F.,Joerger, A.C.,Kraemer, A.,Wanior, M.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-07-15, release date: 2020-10-07, Last modification date: 2024-01-31)

• Primary citation: Wanior, M.,Preuss, F.,Ni, X.,Kramer, A.,Mathea, S.,Gobel, T.,Heidenreich, D.,Simonyi, S.,Kahnt, A.S.,Joerger, A.C.,Knapp, S.; Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis.; J.Med.Chem., 63:14680-14699, 2020; PubMed: 33216538; DOI: 10.1021/acs.jmedchem.0c01242

Experimental method

X-RAY DIFFRACTION (1.57 Å)