6ZRQ
two-protofilament amyloid structure of S20G variant of human amylin (IAPP - islet amyloid polypeptide)
Summary for 6ZRQ
Entry DOI | 10.2210/pdb6zrq/pdb |
Related | 6ZRF |
EMDB information | 11380 11382 |
Descriptor | Islet amyloid polypeptide (1 entity in total) |
Functional Keywords | amyloid fibril type-2-diabetes early-onset, protein fibril |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 12 |
Total formula weight | 46539.52 |
Authors | Gallardo, R.U.,Iadanza, M.G.,Ranson, N.A.,Radford, S.E. (deposition date: 2020-07-14, release date: 2020-09-30, Last modification date: 2020-11-18) |
Primary citation | Gallardo, R.,Iadanza, M.G.,Xu, Y.,Heath, G.R.,Foster, R.,Radford, S.E.,Ranson, N.A. Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly. Nat.Struct.Mol.Biol., 27:1048-1056, 2020 Cited by PubMed: 32929282DOI: 10.1038/s41594-020-0496-3 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
Download full validation report