6ZRH

Crystal structure of OXA-10loop24 in complex with ertapenem

Summary for 6ZRH

• Entry DOI: 10.2210/pdb6zrh/pdb
• Related: 6ZRG
• Descriptor: Beta-lactamase, (2S,3R,4S)-4-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-2-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: beta-lactamase, oxa-10loop24, carbapenem, ertapenem, acylenzyme, laboratory variant, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 4
• Total formula weight: 112287.89

Authors

Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Mangani, S.,Docquier, J.D. (deposition date: 2020-07-13, release date: 2021-07-21, Last modification date: 2024-01-31)

• Primary citation: Tassone, G.,Di Pisa, F.,Benvenuti, M.,De Luca, F.,Pozzi, C.,Mangani, S.,Docquier, J.D.; Mechanistic insights into carbapenem hydrolysis by OXA-48 and the OXA10-derived hybrids OXA-10 loop24 and loop48; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.88 Å)