6ZOR

Oestrogen receptor ligand binding domain in complex with compound 28

Summary for 6ZOR

• Entry DOI: 10.2210/pdb6zor/pdb
• Descriptor: Estrogen receptor, 6-[(6~{S},8~{R})-8-methyl-7-[2,2,2-tris(fluoranyl)ethyl]-3,6,8,9-tetrahydropyrazolo[4,3-f]isoquinolin-6-yl]-~{N}-(1-propylazetidin-3-yl)pyridin-3-amine (3 entities in total)
• Functional Keywords: oestrogen receptor, gene regulation
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 58228.09

Authors

Breed, J. (deposition date: 2020-07-07, release date: 2021-01-20, Last modification date: 2024-01-31)

• Primary citation: Scott, J.S.,Moss, T.A.,Balazs, A.,Barlaam, B.,Breed, J.,Carbajo, R.J.,Chiarparin, E.,Davey, P.R.J.,Delpuech, O.,Fawell, S.,Fisher, D.I.,Gagrica, S.,Gangl, E.T.,Grebe, T.,Greenwood, R.D.,Hande, S.,Hatoum-Mokdad, H.,Herlihy, K.,Hughes, S.,Hunt, T.A.,Huynh, H.,Janbon, S.L.M.,Johnson, T.,Kavanagh, S.,Klinowska, T.,Lawson, M.,Lister, A.S.,Marden, S.,McGinnity, D.F.,Morrow, C.J.,Nissink, J.W.M.,O'Donovan, D.H.,Peng, B.,Polanski, R.,Stead, D.S.,Stokes, S.,Thakur, K.,Throner, S.R.,Tucker, M.J.,Varnes, J.,Wang, H.,Wilson, D.M.,Wu, D.,Wu, Y.,Yang, B.,Yang, W.; Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.; J.Med.Chem., 63:14530-14559, 2020; PubMed: 32910656; DOI: 10.1021/acs.jmedchem.0c01163

Experimental method

X-RAY DIFFRACTION (1.97 Å)