6ZN2

Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding.

Summary for 6ZN2

Entry DOI	10.2210/pdb6zn2/pdb
EMDB information	11309
Descriptor	Tyrosine 3-monooxygenase, SER-LEU-ILE-GLU-ASP-ALA-ARG-LYS-GLU-ARG-GLU-ALA-ALA-VAL-ALA-ALA-ALA-ALA, L-DOPAMINE, ... (4 entities in total)
Functional Keywords	tetramer, dopamine, catecholamine, brain, parkinson, oxidoreductase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	8
Total formula weight	160683.48
Authors	Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Valpuesta, J.M.,Martinez, A.,Flydal, M.I. (deposition date: 2020-07-06, release date: 2021-12-08, Last modification date: 2022-02-02)
Primary citation	Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13:74-74, 2022 Cited by PubMed: 35013193 DOI: 10.1038/s41467-021-27657-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.3 Å)

Structure validation