6ZN0
Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with isonicotinamidine
Summary for 6ZN0
Entry DOI | 10.2210/pdb6zn0/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, (4R)-2-METHYLPENTANE-2,4-DIOL, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41630.49 |
Authors | Oebbeke, M.,Heine, A.,Klebe, G. (deposition date: 2020-07-06, release date: 2020-12-09, Last modification date: 2024-01-31) |
Primary citation | Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60:252-258, 2021 Cited by PubMed: 33021032DOI: 10.1002/anie.202011295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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