6ZL5
CRYSTAL STRUCTURE OF KRAS-G12D(C118S) IN COMPLEX WITH BI-2852 AND GDP
Summary for 6ZL5
Entry DOI | 10.2210/pdb6zl5/pdb |
Descriptor | GTPase KRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total) |
Functional Keywords | gtpase, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 20450.94 |
Authors | Kessler, D.,Fischer, G.,Boettcher, J. (deposition date: 2020-06-30, release date: 2020-08-19, Last modification date: 2024-01-31) |
Primary citation | Kessler, D.,Bergner, A.,Bottcher, J.,Fischer, G.,Dobel, S.,Hinkel, M.,Mullauer, B.,Weiss-Puxbaum, A.,McConnell, D.B. Drugging all RAS isoforms with one pocket. Future Med Chem, 12:1911-1923, 2020 Cited by PubMed: 32779487DOI: 10.4155/fmc-2020-0221 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.645 Å) |
Structure validation
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