6ZK8

Native crystal structure of anaerobic F420H2-Oxidase from Methanothermococcus thermolithotrophicus at 1.8A resolution

6ZK8 の概要

• エントリーDOI: 10.2210/pdb6zk8/pdb
• 分子名称: Coenzyme F420H2 oxidase (FprA), DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ... (7 entities in total)
• 機能のキーワード: oxidase, four electron reduction, oxygen, anaerobic, oxidoreductase
• 由来する生物種: Methanothermococcus thermolithotrophicus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95658.34

構造登録者

Engilberge, S.,Wagner, T.,Carpentier, P.,Girard, E.,Shima, S. (登録日: 2020-06-30, 公開日: 2020-11-25, 最終更新日: 2024-01-31)

主引用文献

Engilberge, S.,Wagner, T.,Carpentier, P.,Girard, E.,Shima, S.
Krypton-derivatization highlights O 2 -channeling in a four-electron reducing oxidase.
Chem.Commun.(Camb.), 56:10863-10866, 2020

PubMed Abstract: F420H2-oxidase (FprA) catalyses the four-electron reduction of O2 to 2H2O using the reduced form of F420 as electron donor. The hydrophobic O2-channel detected by Kr-derivatization and the concerted movement of a gating loop could contribute to prevent unwanted side-reaction between the catalytic intermediates and solvents, therefore preventing reactive oxygen species formation.

PubMed: 32940290
DOI: 10.1039/d0cc04557h

実験手法

X-RAY DIFFRACTION (1.83 Å)