6ZJZ

Discovery of M5049: a novel selective TLR7/8 inhibitor for treatment of autoimmunity

Summary for 6ZJZ

• Entry DOI: 10.2210/pdb6zjz/pdb
• Descriptor: Toll-like receptor 8, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: leucine rich repeat, rna, glycosylation, innate immunity, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 190947.93

Authors

Musil, D.,Lehman, M.,Strauss, J. (deposition date: 2020-06-29, release date: 2020-12-30, Last modification date: 2024-01-31)

• Primary citation: Vlach, J.,Bender, A.T.,Przetak, M.,Pereira, A.,Deshpande, A.,Johnson, T.L.,Reissig, S.,Tzvetkov, E.,Musil, D.,Morse, N.T.,Haselmayer, P.,Zimmerli, S.C.,Okitsu, S.L.,Walsky, R.L.,Sherer, B.; Discovery of M5049: A Novel Selective Toll-Like Receptor 7/8 Inhibitor for Treatment of Autoimmunity.; J.Pharmacol.Exp.Ther., 376:397-409, 2021; PubMed: 33328334; DOI: 10.1124/jpet.120.000275

Experimental method

X-RAY DIFFRACTION (2.489 Å)