6ZFN

Structure of an inactive E404Q variant of the catalytic domain of human endo-alpha-mannosidase MANEA in complex with 1-methyl alpha-1,2-mannobiose

これはPDB形式変換不可エントリーです。

6ZFN の概要

• エントリーDOI: 10.2210/pdb6zfn/pdb
• 分子名称: Glycoprotein endo-alpha-1,2-mannosidase, alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: golgi, hydrolase, mannosidase, retaining
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45234.49

構造登録者

Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J. (登録日: 2020-06-17, 公開日: 2020-11-18, 最終更新日: 2024-01-24)

• 主引用文献: Sobala, L.F.,Fernandes, P.Z.,Hakki, Z.,Thompson, A.J.,Howe, J.D.,Hill, M.,Zitzmann, N.,Davies, S.,Stamataki, Z.,Butters, T.D.,Alonzi, D.S.,Williams, S.J.,Davies, G.J.; Structure of human endo-alpha-1,2-mannosidase (MANEA), an antiviral host-glycosylation target.; Proc.Natl.Acad.Sci.USA, 117:29595-29601, 2020; PubMed: 33154157; DOI: 10.1073/pnas.2013620117

実験手法

X-RAY DIFFRACTION (1.1 Å)