6ZEW

Keap1 kelch domain bound to a small molecule fragment

Summary for 6ZEW

Entry DOI	10.2210/pdb6zew/pdb
Descriptor	Kelch-like ECH-associated protein 1, DIMETHYL SULFOXIDE, SULFATE ION, ... (5 entities in total)
Functional Keywords	keap1, nrf2, oxidative stress, small molecule complex, peptide binding protein
Biological source	Mus musculus (House mouse)
Total number of polymer chains	1
Total formula weight	34232.57
Authors	Narayanan, D.,Bach, A.,Gajhede, M. (deposition date: 2020-06-16, release date: 2021-04-14, Last modification date: 2024-01-24)
Primary citation	Pallesen, J.S.,Narayanan, D.,Tran, K.T.,Solbak, S.M.O.,Marseglia, G.,Sorensen, L.M.E.,Hoj, L.J.,Munafo, F.,Carmona, R.M.C.,Garcia, A.D.,Desu, H.L.,Brambilla, R.,Johansen, T.N.,Popowicz, G.M.,Sattler, M.,Gajhede, M.,Bach, A. Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. J.Med.Chem., 64:4623-4661, 2021 Cited by PubMed: 33818106 DOI: 10.1021/acs.jmedchem.0c02094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.38 Å)

Structure validation