6ZC4
Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
Summary for 6ZC4
| Entry DOI | 10.2210/pdb6zc4/pdb |
| Descriptor | Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b, 5-bromanyl-2-(5,6,7,8-tetrahydronaphthalen-2-ylsulfonylamino)benzoic acid (3 entities in total) |
| Functional Keywords | pdz, dvl, inhibitors, wnt, signalling, peptide binding protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 21219.93 |
| Authors | Roske, Y.,Heinemann, U.,Oschkinat, H. (deposition date: 2020-06-09, release date: 2021-06-23, Last modification date: 2024-01-24) |
| Primary citation | Roske, Y.,Heinemann, U.,Oschkinat, H.,Kamdem, N.,Kovalskyy, D.,Platonov, M.O.,Balinskyi, O.M.,Kreuchwig, A.,Saupe, J.,Fang, L.,Diehl, A.,Schmieder, P.,Krause, G.,Rademann, J.,Birchmeier, W. Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling J.Magn.Reson., 2021 Cited by DOI: 10.5194/mr-2-355-2021PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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