6ZC3

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

Summary for 6ZC3

• Entry DOI: 10.2210/pdb6zc3/pdb
• Descriptor: Dishevelled, dsh homolog 3 (Drosophila), isoform CRA_b, 1,2-ETHANEDIOL, 5-fluoranyl-2-(methylsulfonylamino)benzoic acid, ... (4 entities in total)
• Functional Keywords: pdz, dvl, inhibitors, wnt, signalling, peptide binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 20927.86

Authors

Roske, Y.,Heinemann, U.,Oschkinat, H. (deposition date: 2020-06-09, release date: 2021-06-23, Last modification date: 2024-01-24)

• Primary citation: Roske, Y.,Heinemann, U.,Oschkinat, H.,Kamdem, N.,Kovalskyy, D.,Platonov, M.O.,Balinskyi, O.M.,Kreuchwig, A.,Saupe, J.,Fang, L.,Diehl, A.,Schmieder, P.,Krause, G.,Rademann, J.,Birchmeier, W.; Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling; J.Magn.Reson., 2021; DOI: 10.5194/mr-2-355-2021

Experimental method

X-RAY DIFFRACTION (1.67 Å)