6ZBO

HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in Complex with 1-(6-morpholinopyrimidin-4-yl)-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-5-ol (Molidustat)

Summary for 6ZBO

Entry DOI	10.2210/pdb6zbo/pdb
Descriptor	Egl nine homolog 1, MANGANESE (II) ION, 2-(6-morpholin-4-ylpyrimidin-4-yl)-4-(1,2,3-triazol-1-yl)pyrazol-3-ol, ... (5 entities in total)
Functional Keywords	phd2, inhibitor, complex, molidustat, oxidoreductase, hif
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	155466.07
Authors	Figg Jr, W.D.,McDonough, M.A.,Nakashima, Y.,Holt-Martyn, J.P.,Schofield, C.J. (deposition date: 2020-06-08, release date: 2021-04-07, Last modification date: 2024-01-24)
Primary citation	Figg Jr., W.D.,McDonough, M.A.,Chowdhury, R.,Nakashima, Y.,Zhang, Z.,Holt-Martyn, J.P.,Krajnc, A.,Schofield, C.J. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem, 16:2082-2088, 2021 Cited by PubMed: 33792169 DOI: 10.1002/cmdc.202100133 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation