6ZBN

HIF Prolyl Hydroxylase 2 (PHD2/EGLN1) in complex with tert-butyl 6-(5-hydroxy-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl)nicotinate (IOX4)

Summary for 6ZBN

Entry DOI	10.2210/pdb6zbn/pdb
Descriptor	Egl nine homolog 1, ~{tert}-butyl 6-[5-oxidanyl-4-(1,2,3-triazol-1-yl)pyrazol-1-yl]pyridine-3-carboxylate, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywords	inhibitor, complex, oxidoreductase, iox4, hif, phd2, hypoxia
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	155181.41
Authors	Figg Jr, W.D.,McDonough, M.A.,Nakashima, Y.,Schofield, C.J. (deposition date: 2020-06-08, release date: 2021-04-07, Last modification date: 2024-01-24)
Primary citation	Figg Jr., W.D.,McDonough, M.A.,Chowdhury, R.,Nakashima, Y.,Zhang, Z.,Holt-Martyn, J.P.,Krajnc, A.,Schofield, C.J. Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. Chemmedchem, 16:2082-2088, 2021 Cited by PubMed: 33792169 DOI: 10.1002/cmdc.202100133 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation