6ZAQ

Room temperature XFEL Isopenicillin N synthase structure in complex with Fe and IPN after dioxygen exposure

Summary for 6ZAQ

• Entry DOI: 10.2210/pdb6zaq/pdb
• Related: 1BLZ 1QJE
• Descriptor: Isopenicillin N synthase, FE (II) ION, SULFATE ION, ... (5 entities in total)
• Functional Keywords: isopenicillin n synthase, oxygen binding, xfel, time-resolved crystallography, oxidoreductase
• Biological source: Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
• Total number of polymer chains: 1
• Total formula weight: 38075.14

Authors

Rabe, P.,Kamps, J.J.A.G.,Sutherlin, K.,Pharm, C.,McDonough, M.A.,Leissing, T.M.,Aller, P.,Butryn, A.,Linyard, J.,Lang, P.,Brem, J.,Fuller, F.D.,Batyuk, A.,Hunter, M.S.,Pettinati, I.,Clifton, I.J.,Alonso-Mori, R.,Gul, S.,Young, I.,Kim, I.,Bhowmick, A.,ORiordan, L.,Brewster, A.S.,Claridge, T.D.W.,Sauter, N.K.,Yachandra, V.,Yano, J.,Kern, J.F.,Orville, A.M.,Schofield, C.J. (deposition date: 2020-06-05, release date: 2021-06-09, Last modification date: 2024-01-24)

• Primary citation: Rabe, P.,Kamps, J.J.A.G.,Sutherlin, K.D.,Linyard, J.D.S.,Aller, P.,Pham, C.C.,Makita, H.,Clifton, I.,McDonough, M.A.,Leissing, T.M.,Shutin, D.,Lang, P.A.,Butryn, A.,Brem, J.,Gul, S.,Fuller, F.D.,Kim, I.S.,Cheah, M.H.,Fransson, T.,Bhowmick, A.,Young, I.D.,O'Riordan, L.,Brewster, A.S.,Pettinati, I.,Doyle, M.,Joti, Y.,Owada, S.,Tono, K.,Batyuk, A.,Hunter, M.S.,Alonso-Mori, R.,Bergmann, U.,Owen, R.L.,Sauter, N.K.,Claridge, T.D.W.,Robinson, C.V.,Yachandra, V.K.,Yano, J.,Kern, J.F.,Orville, A.M.,Schofield, C.J.; X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis.; Sci Adv, 7:-, 2021; PubMed: 34417180; DOI: 10.1126/sciadv.abh0250

Experimental method

X-RAY DIFFRACTION (1.6 Å)