6Z7V

Crystal structure of Mindy2 (C266A) in complex with Lys48 linked di-ubiquitin (K48-Ub2)

Summary for 6Z7V

Entry DOI	10.2210/pdb6z7v/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase MINDY-2, Polyubiquitin-C, POTASSIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, cysteine protease, isopeptidase and ubiquitin binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	9
Total formula weight	123113.67
Authors	Abdul Rehman, S.A.,Lange, S.M.,Kulathu, Y. (deposition date: 2020-06-01, release date: 2021-06-09, Last modification date: 2024-01-24)
Primary citation	Abdul Rehman, S.A.,Armstrong, L.A.,Lange, S.M.,Kristariyanto, Y.A.,Grawert, T.W.,Knebel, A.,Svergun, D.I.,Kulathu, Y. Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2. Mol.Cell, 81:4176-4190.e6, 2021 Cited by PubMed: 34529927 DOI: 10.1016/j.molcel.2021.08.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation