Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6Z7G

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide

This is a non-PDB format compatible entry.
Summary for 6Z7G
Entry DOI10.2210/pdb6z7g/pdb
DescriptorBromodomain-containing protein 4, N-(2-(1H-imidazol-4-yl)ethyl)-4-acetamido-3-(benzyloxy)benzamide (3 entities in total)
Functional Keywordsinhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight15477.80
Authors
Chung, C. (deposition date: 2020-05-30, release date: 2020-07-29, Last modification date: 2020-09-23)
Primary citationPreston, A.,Atkinson, S.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Gray, J.R.J.,Jones, E.J.,Lindon, M.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rianjongdee, F.,Rioja, I.,Seal, J.,Taylor, S.,Wall, I.,Watson, R.J.,Woolven, J.,Demont, E.H.
Design and Synthesis of a Highly Selective andIn Vivo-Capable Inhibitor of the Second Bromodomain of the Bromodomain and Extra Terminal Domain Family of Proteins.
J.Med.Chem., 63:9070-9092, 2020
Cited by
PubMed: 32691591
DOI: 10.1021/acs.jmedchem.0c00605
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.59 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon