6Z7E

Variant Surface Glycoprotein VSGsur mutant H122A soaked in 7.7 mM suramin

Summary for 6Z7E

Entry DOI	10.2210/pdb6z7e/pdb
Descriptor	Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	variant surface glycoprotein suramin trypanosomiasis drug resistance glycosylation vsg, membrane protein
Biological source	Trypanosoma brucei rhodesiense
Total number of polymer chains	1
Total formula weight	53311.84
Authors	Zeelen, J.P.,Straaten van, M.,Stebbins, C.E. (deposition date: 2020-05-30, release date: 2021-03-17, Last modification date: 2024-01-24)
Primary citation	Zeelen, J.,van Straaten, M.,Verdi, J.,Hempelmann, A.,Hashemi, H.,Perez, K.,Jeffrey, P.D.,Halg, S.,Wiedemar, N.,Maser, P.,Papavasiliou, F.N.,Stebbins, C.E. Structure of trypanosome coat protein VSGsur and function in suramin resistance. Nat Microbiol, 6:392-400, 2021 Cited by PubMed: 33462435 DOI: 10.1038/s41564-020-00844-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.663 Å)

Structure validation