6Z7B

Variant Surface Glycoprotein VSGsur bound to suramin

6Z7B の概要

• エントリーDOI: 10.2210/pdb6z7b/pdb
• 分子名称: Variant surface glycoprotein Sur, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: variant surface glycoprotein suramin trypanosomiasis drug resistance glycosylation vsg, membrane protein
• 由来する生物種: Trypanosoma brucei rhodesiense
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 109352.22

構造登録者

Zeelen, J.P.,Straaten van, M.,Stebbins, C.E.,Jeffrey, P. (登録日: 2020-05-30, 公開日: 2021-03-24, 最終更新日: 2024-01-24)

• 主引用文献: Zeelen, J.,van Straaten, M.,Verdi, J.,Hempelmann, A.,Hashemi, H.,Perez, K.,Jeffrey, P.D.,Halg, S.,Wiedemar, N.,Maser, P.,Papavasiliou, F.N.,Stebbins, C.E.; Structure of trypanosome coat protein VSGsur and function in suramin resistance.; Nat Microbiol, 6:392-400, 2021; PubMed: 33462435; DOI: 10.1038/s41564-020-00844-1

実験手法

X-RAY DIFFRACTION (1.86 Å)