6Z4D

Crystal Structure of EGFR-T790M/V948R in Complex with Mavelertinib and EAI001

6Z4D の概要

• エントリーDOI: 10.2210/pdb6z4d/pdb
• 分子名称: Epidermal growth factor receptor, N-[(3R,4R)-4-fluoro-1-{6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl}pyrrolidin-3-yl]propanamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: egfr, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77592.42

構造登録者

Niggenaber, J.,Mueller, M.P.,Rauh, D. (登録日: 2020-05-25, 公開日: 2020-11-11, 最終更新日: 2024-01-24)

• 主引用文献: Niggenaber, J.,Heyden, L.,Grabe, T.,Muller, M.P.,Lategahn, J.,Rauh, D.; Complex Crystal Structures of EGFR with Third-Generation Kinase Inhibitors and Simultaneously Bound Allosteric Ligands.; Acs Med.Chem.Lett., 11:2484-2490, 2020; PubMed: 33335671; DOI: 10.1021/acsmedchemlett.0c00472

実験手法

X-RAY DIFFRACTION (2 Å)