6Z2X
Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP (State II)
Summary for 6Z2X
Entry DOI | 10.2210/pdb6z2x/pdb |
EMDB information | 11050 11051 |
Descriptor | DNA damage checkpoint protein LCD1, Serine/threonine-protein kinase MEC1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | serine/threonine protein kinase, complex, dna damage response, checkpoint control, hydrolase |
Biological source | Saccharomyces cerevisiae S288C More |
Total number of polymer chains | 4 |
Total formula weight | 721601.24 |
Authors | Yates, L.A.,Zhang, X. (deposition date: 2020-05-18, release date: 2020-11-11, Last modification date: 2024-05-22) |
Primary citation | Tannous, E.A.,Yates, L.A.,Zhang, X.,Burgers, P.M. Mechanism of auto-inhibition and activation of Mec1 ATR checkpoint kinase. Nat.Struct.Mol.Biol., 28:50-61, 2021 Cited by PubMed: 33169019DOI: 10.1038/s41594-020-00522-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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