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6Z2X

Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP (State II)

Functional Information from GO Data
ChainGOidnamespacecontents
C0000077biological_processDNA damage checkpoint signaling
C0000228cellular_componentnuclear chromosome
C0003684molecular_functiondamaged DNA binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0006139biological_processnucleobase-containing compound metabolic process
C0006281biological_processDNA repair
C0006325biological_processchromatin organization
C0007004biological_processtelomere maintenance via telomerase
C0045184biological_processestablishment of protein localization
C0070310cellular_componentATR-ATRIP complex
C2000779biological_processregulation of double-strand break repair
D0000077biological_processDNA damage checkpoint signaling
D0000228cellular_componentnuclear chromosome
D0003684molecular_functiondamaged DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0006139biological_processnucleobase-containing compound metabolic process
D0006281biological_processDNA repair
D0006325biological_processchromatin organization
D0007004biological_processtelomere maintenance via telomerase
D0045184biological_processestablishment of protein localization
D0070310cellular_componentATR-ATRIP complex
D2000779biological_processregulation of double-strand break repair
E0000077biological_processDNA damage checkpoint signaling
E0000722biological_processtelomere maintenance via recombination
E0000723biological_processtelomere maintenance
E0004672molecular_functionprotein kinase activity
E0004674molecular_functionprotein serine/threonine kinase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005694cellular_componentchromosome
E0005739cellular_componentmitochondrion
E0006139biological_processnucleobase-containing compound metabolic process
E0006260biological_processDNA replication
E0006281biological_processDNA repair
E0006310biological_processDNA recombination
E0006325biological_processchromatin organization
E0006338biological_processchromatin remodeling
E0007131biological_processreciprocal meiotic recombination
E0016301molecular_functionkinase activity
E0016310biological_processphosphorylation
E0019222biological_processregulation of metabolic process
E0033554biological_processcellular response to stress
E0035556biological_processintracellular signal transduction
E0042770biological_processsignal transduction in response to DNA damage
E0044024molecular_functionhistone H2AS1 kinase activity
E0051321biological_processmeiotic cell cycle
E0070310cellular_componentATR-ATRIP complex
E0106310molecular_functionprotein serine kinase activity
E2000105biological_processpositive regulation of DNA-templated DNA replication
E2000779biological_processregulation of double-strand break repair
F0000077biological_processDNA damage checkpoint signaling
F0000722biological_processtelomere maintenance via recombination
F0000723biological_processtelomere maintenance
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005739cellular_componentmitochondrion
F0006139biological_processnucleobase-containing compound metabolic process
F0006260biological_processDNA replication
F0006281biological_processDNA repair
F0006310biological_processDNA recombination
F0006325biological_processchromatin organization
F0006338biological_processchromatin remodeling
F0007131biological_processreciprocal meiotic recombination
F0016301molecular_functionkinase activity
F0016310biological_processphosphorylation
F0019222biological_processregulation of metabolic process
F0033554biological_processcellular response to stress
F0035556biological_processintracellular signal transduction
F0042770biological_processsignal transduction in response to DNA damage
F0044024molecular_functionhistone H2AS1 kinase activity
F0051321biological_processmeiotic cell cycle
F0070310cellular_componentATR-ATRIP complex
F0106310molecular_functionprotein serine kinase activity
F2000105biological_processpositive regulation of DNA-templated DNA replication
F2000779biological_processregulation of double-strand break repair
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue ANP E 2401
ChainResidue
ESER2058
EHIS2226
EGLU2228
EASN2229
EVAL2242
EASP2243
EMG2403
EMG2404
ELYS2060
EPRO2062
ELYS2080
EGLU2130
EMET2131
EVAL2132
EVAL2135
ETHR2137

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN E 2402
ChainResidue
ECYS467
ECYS490
ECYS493
EHIS553

site_idAC3
Number of Residues3
Detailsbinding site for residue MG E 2403
ChainResidue
EASN2229
EASP2243
EANP2401

site_idAC4
Number of Residues4
Detailsbinding site for residue MG E 2404
ChainResidue
EGLU2082
EASP2243
EASP2245
EANP2401

site_idAC5
Number of Residues16
Detailsbinding site for residue ANP F 2401
ChainResidue
FSER2058
FLYS2060
FPRO2062
FLYS2080
FGLU2130
FMET2131
FVAL2132
FVAL2135
FTHR2137
FHIS2226
FGLU2228
FASN2229
FVAL2242
FASP2243
FMG2403
FMG2404

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN F 2402
ChainResidue
FCYS467
FCYS490
FCYS493
FHIS553

site_idAC7
Number of Residues3
Detailsbinding site for residue MG F 2403
ChainResidue
FASN2229
FASP2243
FANP2401

site_idAC8
Number of Residues4
Detailsbinding site for residue MG F 2404
ChainResidue
FGLU2082
FASP2243
FASP2245
FANP2401

Functional Information from PROSITE/UniProt
site_idPS00915
Number of Residues14
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. CKk..EDVRQDnqymQ
ChainResidueDetails
ECYS2079-GLN2092

site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SyAvmaMvgHILgLgDRHceN
ChainResidueDetails
ESER2209-ASN2229

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
DSER10
DSER11
DSER76
CSER10
CSER11
CSER76

224572

PDB entries from 2024-09-04

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