6Z2X

Mec1-Ddc2 (F2244L mutant) in complex with Mg AMP-PNP (State II)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000077	biological_process	DNA damage checkpoint signaling
C	0000228	cellular_component	nuclear chromosome
C	0003684	molecular_function	damaged DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0007004	biological_process	telomere maintenance via telomerase
C	0045184	biological_process	establishment of protein localization
C	2000779	biological_process	regulation of double-strand break repair
D	0000077	biological_process	DNA damage checkpoint signaling
D	0000228	cellular_component	nuclear chromosome
D	0003684	molecular_function	damaged DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0007004	biological_process	telomere maintenance via telomerase
D	0045184	biological_process	establishment of protein localization
D	2000779	biological_process	regulation of double-strand break repair
E	0000077	biological_process	DNA damage checkpoint signaling
E	0000722	biological_process	telomere maintenance via recombination
E	0000723	biological_process	telomere maintenance
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005657	cellular_component	replication fork
E	0005694	cellular_component	chromosome
E	0005739	cellular_component	mitochondrion
E	0006260	biological_process	DNA replication
E	0006275	biological_process	regulation of DNA replication
E	0006281	biological_process	DNA repair
E	0006310	biological_process	DNA recombination
E	0007131	biological_process	reciprocal meiotic recombination
E	0016301	molecular_function	kinase activity
E	0042770	biological_process	signal transduction in response to DNA damage
E	0051276	biological_process	chromosome organization
E	0106310	molecular_function	protein serine kinase activity
E	1904594	biological_process	regulation of termination of RNA polymerase II transcription
E	2000105	biological_process	positive regulation of DNA-templated DNA replication
E	2000779	biological_process	regulation of double-strand break repair
F	0000077	biological_process	DNA damage checkpoint signaling
F	0000722	biological_process	telomere maintenance via recombination
F	0000723	biological_process	telomere maintenance
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005657	cellular_component	replication fork
F	0005694	cellular_component	chromosome
F	0005739	cellular_component	mitochondrion
F	0006260	biological_process	DNA replication
F	0006275	biological_process	regulation of DNA replication
F	0006281	biological_process	DNA repair
F	0006310	biological_process	DNA recombination
F	0007131	biological_process	reciprocal meiotic recombination
F	0016301	molecular_function	kinase activity
F	0042770	biological_process	signal transduction in response to DNA damage
F	0051276	biological_process	chromosome organization
F	0106310	molecular_function	protein serine kinase activity
F	1904594	biological_process	regulation of termination of RNA polymerase II transcription
F	2000105	biological_process	positive regulation of DNA-templated DNA replication
F	2000779	biological_process	regulation of double-strand break repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ANP E 2401

Chain	Residue
E	SER2058
E	HIS2226
E	GLU2228
E	ASN2229
E	VAL2242
E	ASP2243
E	MG2403
E	MG2404
E	LYS2060
E	PRO2062
E	LYS2080
E	GLU2130
E	MET2131
E	VAL2132
E	VAL2135
E	THR2137

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN E 2402

Chain	Residue
E	CYS467
E	CYS490
E	CYS493
E	HIS553

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG E 2403

Chain	Residue
E	ASN2229
E	ASP2243
E	ANP2401

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG E 2404

Chain	Residue
E	GLU2082
E	ASP2243
E	ASP2245
E	ANP2401

---

site_id	AC5
Number of Residues	16
Details	binding site for residue ANP F 2401

Chain	Residue
F	SER2058
F	LYS2060
F	PRO2062
F	LYS2080
F	GLU2130
F	MET2131
F	VAL2132
F	VAL2135
F	THR2137
F	HIS2226
F	GLU2228
F	ASN2229
F	VAL2242
F	ASP2243
F	MG2403
F	MG2404

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN F 2402

Chain	Residue
F	CYS467
F	CYS490
F	CYS493
F	HIS553

---

site_id	AC7
Number of Residues	3
Details	binding site for residue MG F 2403

Chain	Residue
F	ASN2229
F	ASP2243
F	ANP2401

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG F 2404

Chain	Residue
F	GLU2082
F	ASP2243
F	ASP2245
F	ANP2401

---

Functional Information from PROSITE/UniProt

site_id	PS00915
Number of Residues	14
Details	PI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. CKk..EDVRQDnqymQ

Chain	Residue	Details
E	CYS2079-GLN2092

---

site_id	PS00916
Number of Residues	21
Details	PI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SyAvmaMvgHILgLgDRHceN

Chain	Residue	Details
E	SER2209-ASN2229

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	606
Details	Domain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Domain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Region: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	456
Details	Region: {"description":"Binding to the RPA complex"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Region: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	48
Details	Region: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---