6Z25

Acylenzyme complex of ceftazidime bound to deacylation mutant KPC-4 (E166Q)

Summary for 6Z25

Entry DOI	10.2210/pdb6z25/pdb
Descriptor	Beta-lactamase, GLYCEROL, ACYLATED CEFTAZIDIME, ... (5 entities in total)
Functional Keywords	unliganded beta-lactamase, 3-layer alpha-beta-alpha sandwich, part of the dd-peptidase and beta-lactamase superfamily., antimicrobial protein
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	32141.83
Authors	Tooke, C.L.,Hinchliffe, P.,Spencer, J. (deposition date: 2020-05-14, release date: 2020-12-23, Last modification date: 2024-01-24)
Primary citation	Tooke, C.L.,Hinchliffe, P.,Bonomo, R.A.,Schofield, C.J.,Mulholland, A.J.,Spencer, J. Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance. J.Biol.Chem., 296:100126-100126, 2020 Cited by PubMed: 33257320 DOI: 10.1074/jbc.RA120.016461 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.24 Å)

Structure validation