6Z1A
Ternary complex of Staphylococcus aureus DNA gyrase with AMK12 and DNA
Summary for 6Z1A
Entry DOI | 10.2210/pdb6z1a/pdb |
Descriptor | DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-D(*AP*GP*CP*CP*GP*TP*AP*G)-3'), DNA (5'-D(P*GP*TP*AP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ... (9 entities in total) |
Functional Keywords | type iia topoisomerase, antibacterial, inhibitor, isomerase, fusion protein |
Biological source | Staphylococcus aureus More |
Total number of polymer chains | 6 |
Total formula weight | 169715.13 |
Authors | Kolaric, A.,Germe, T.,Hrast, M.,Stevenson, C.E.M.,Lawson, D.M.,Burton, N.,Voros, J.,Maxwell, A.,Minovski, N.,Anderluh, M. (deposition date: 2020-05-13, release date: 2020-11-11, Last modification date: 2024-01-24) |
Primary citation | Kolaric, A.,Germe, T.,Hrast, M.,Stevenson, C.E.M.,Lawson, D.M.,Burton, N.P.,Voros, J.,Maxwell, A.,Minovski, N.,Anderluh, M. Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds. Nat Commun, 12:150-150, 2021 Cited by PubMed: 33420011DOI: 10.1038/s41467-020-20405-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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