6Z0I
Structure of the TREM2 transmembrane helix in complex with DAP12 in DPC micelles
Summary for 6Z0I
| Entry DOI | 10.2210/pdb6z0i/pdb |
| Related | 6Z0G 6Z0H |
| NMR Information | BMRB: 50265 |
| Descriptor | Triggering receptor expressed on myeloid cells 2 (1 entity in total) |
| Functional Keywords | neurodegeneration, proteolysis, membrane protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 5172.12 |
| Authors | Steiner, A.,Schlepkow, K.,Brunner, B.,Steiner, H.,Haass, C.,Hagn, F. (deposition date: 2020-05-08, release date: 2020-09-16, Last modification date: 2023-06-14) |
| Primary citation | Steiner, A.,Schlepckow, K.,Brunner, B.,Steiner, H.,Haass, C.,Hagn, F. gamma-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics. Embo J., :e104247-e104247, 2020 Cited by PubMed: 32830336DOI: 10.15252/embj.2019104247 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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