6YZ4

Crystal structure of MKK7 (MAP2K7) with ibrutinib bound at allosteric site

Summary for 6YZ4

Entry DOI	10.2210/pdb6yz4/pdb
Descriptor	Dual specificity mitogen-activated protein kinase kinase 7, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	kinase, kinase inhibitor, allosteric, mkk7, mek7, map2k7, map2k, mek, jnk signaling, structural genomics, structural genomics consortium, sgc, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36256.26
Authors	Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-05-06, release date: 2020-08-12, Last modification date: 2024-01-24)
Primary citation	Schroder, M.,Tan, L.,Wang, J.,Liang, Y.,Gray, N.S.,Knapp, S.,Chaikuad, A. Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities. Cell Chem Biol, 27:1285-1295.e4, 2020 Cited by PubMed: 32783966 DOI: 10.1016/j.chembiol.2020.07.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation