6YWK
Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with HEPES
Summary for 6YWK
Entry DOI | 10.2210/pdb6ywk/pdb |
Descriptor | NSP3 macrodomain, 1,2-ETHANEDIOL, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | nsp3, macrodomain, adp-ribose-1"-phosphatase, adrp, covid-19, sars-cov-2, structural genomics, structural genomics consortium, sgc, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 5 |
Total formula weight | 95510.89 |
Authors | Ni, X.,Schroeder, M.,Olieric, V.,Sharpe, E.M.,Wojdyla, J.A.,Wang, M.,Knapp, S.,Chaikuad, A.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-29, release date: 2020-05-06, Last modification date: 2024-01-24) |
Primary citation | Ni, X.,Schroder, M.,Olieric, V.,Sharpe, M.E.,Hernandez-Olmos, V.,Proschak, E.,Merk, D.,Knapp, S.,Chaikuad, A. Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain. Acs Med.Chem.Lett., 12:603-609, 2021 Cited by PubMed: 33850605DOI: 10.1021/acsmedchemlett.0c00684 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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