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6YWK

Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with HEPES

Summary for 6YWK
Entry DOI10.2210/pdb6ywk/pdb
DescriptorNSP3 macrodomain, 1,2-ETHANEDIOL, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordsnsp3, macrodomain, adp-ribose-1"-phosphatase, adrp, covid-19, sars-cov-2, structural genomics, structural genomics consortium, sgc, viral protein
Biological sourceSevere acute respiratory syndrome coronavirus 2 (2019-nCoV)
Total number of polymer chains5
Total formula weight95510.89
Authors
Ni, X.,Schroeder, M.,Olieric, V.,Sharpe, E.M.,Wojdyla, J.A.,Wang, M.,Knapp, S.,Chaikuad, A.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-29, release date: 2020-05-06, Last modification date: 2024-01-24)
Primary citationNi, X.,Schroder, M.,Olieric, V.,Sharpe, M.E.,Hernandez-Olmos, V.,Proschak, E.,Merk, D.,Knapp, S.,Chaikuad, A.
Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.
Acs Med.Chem.Lett., 12:603-609, 2021
Cited by
PubMed: 33850605
DOI: 10.1021/acsmedchemlett.0c00684
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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