6YW0

Lysine-N,N-Dimethylated HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with BB-287

6YW0 の概要

• エントリーDOI: 10.2210/pdb6yw0/pdb
• 関連するPDBエントリー: 4BQW 4BQX 4BQY 6YVW 6YVX 6YVZ
• 分子名称: Egl nine homolog 1, FE (III) ION, 4-(isoquinolin-3-ylamino)-4-oxobutanoic acid, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29026.00

構造登録者

Chowdhury, R.,Schofield, C.J. (登録日: 2020-04-29, 公開日: 2020-12-30, 最終更新日: 2024-01-24)

• 主引用文献: Chowdhury, R.,Abboud, M.I.,McAllister, T.E.,Banerji, B.,Bhushan, B.,Sorensen, J.L.,Kawamura, A.,Schofield, C.J.; Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2.; Sci Rep, 10:21964-21964, 2020; PubMed: 33319810; DOI: 10.1038/s41598-020-76307-8

実験手法

X-RAY DIFFRACTION (2.2 Å)