6YW0

Lysine-N,N-Dimethylated HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with BB-287

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0031418	molecular_function	L-ascorbic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FE A 501

Chain	Residue
A	HIS313
A	ASP315
A	HIS374
A	2JP502
A	HOH623

---

site_id	AC2
Number of Residues	14
Details	binding site for residue 2JP A 502

Chain	Residue
A	TYR329
A	HIS374
A	VAL376
A	ARG383
A	ALA385
A	VAL401
A	FE501
A	HOH623
A	HOH640
A	HOH644
A	TYR310
A	HIS313
A	ASP315
A	ILE327

---

site_id	AC3
Number of Residues	3
Details	binding site for residue BCT A 503

Chain	Residue
A	MLY262
A	ARG312
A	PRO373

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16782814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19604478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28594552","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2G19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3HQU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V18","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"21601578","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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