6YUM

CK2 alpha bound to unclosed Macrocycle

This is a large structure.

Summary for 6YUM

DescriptorCasein kinase II subunit alpha, SULFATE ION, 4-[5-[2-(2-hydroxyethyloxy)ethyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]pyrazolo[1,5-a]pyrimidin-3-yl]-2-oxidanyl-benzoic acid, ... (4 entities in total)
Functional Keywordskinase, macrocycle, inhibitor, structural genomics, structural genomics consortium, sgc, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight91910.42
Authors
Kraemer, A.,Hanke, T.,Kurz, C.,Celik, I.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-27, release date: 2020-07-01)
Primary citation
Kraemer, A.,Hanke, T.,Kurz, C.,Celik, I.,Knapp, S.,Structural Genomics Consortium (SGC)
CK2 alpha bound to unclosed Macrocycle
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.75 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2823 0.2% 3.3% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload