6YSY

Skeletal Myosin bound to MPH-220, MgADP-VO4

Summary for 6YSY

Entry DOI	10.2210/pdb6ysy/pdb
Descriptor	Myosin-4, Myosin light chain 1/3, skeletal muscle isoform, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
Functional Keywords	myofibril, muscle spasticity, actin binding, inhibitor, motor protein
Biological source	Oryctolagus cuniculus (Rabbit) More
Total number of polymer chains	2
Total formula weight	245409.77
Authors	Canon, L.,Kikuti, C.M.,Gyimesi, M.,Malnasi-Csizmadia, A.,Houdusse, A. (deposition date: 2020-04-23, release date: 2021-03-03, Last modification date: 2024-01-24)
Primary citation	Gyimesi, M.,Horvath, A.I.,Turos, D.,Suthar, S.K.,Penzes, M.,Kurdi, C.,Canon, L.,Kikuti, C.,Ruppel, K.M.,Trivedi, D.V.,Spudich, J.A.,Lorincz, I.,Rauscher, A.A.,Kovacs, M.,Pal, E.,Komoly, S.,Houdusse, A.,Malnasi-Csizmadia, A. Single Residue Variation in Skeletal Muscle Myosin Enables Direct and Selective Drug Targeting for Spasticity and Muscle Stiffness. Cell, 183:335-346.e13, 2020 Cited by PubMed: 33035452 DOI: 10.1016/j.cell.2020.08.050 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.246 Å)

Structure validation