6YRH

Transaldolase variant T30C/D211C from T. acidophilum in complex with D-fructose 6-phosphate Schiff-base intermediate

Summary for 6YRH

• Entry DOI: 10.2210/pdb6yrh/pdb
• Related: 6YR3 6YRE
• Descriptor: Probable transaldolase, FRUCTOSE -6-PHOSPHATE, GLYCEROL, ... (5 entities in total)
• Functional Keywords: alpha-beta barrel, conformational selection, domain swapping, transferase, tim barrel, schiff base, large-scale motions, substrate binding, rate-determining product release
• Biological source: Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
• Total number of polymer chains: 5
• Total formula weight: 124571.66

Authors

Sautner, V.,Lietzow, T.H.,Tittmann, K. (deposition date: 2020-04-20, release date: 2021-05-12, Last modification date: 2024-01-24)

• Primary citation: Sautner, V.,Lietzow, T.H.,Klaus, M.,Funk, L.M.,Tittmann, K.; Large-scale motions underlie physical but not chemical steps in transaldolase mechanism: Substrate binding by conformational selection and rate-determining product release; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.8 Å)