6YQW
BRD9 with 4-chloro-2-methyl-methylamino-pyridazinone
Summary for 6YQW
Entry DOI | 10.2210/pdb6yqw/pdb |
Descriptor | Bromodomain-containing protein 9, 4-chloranyl-2-methyl-5-(methylamino)pyridazin-3-one (3 entities in total) |
Functional Keywords | brd9, inhibitor, histone, epigenetic reader, bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 12401.80 |
Authors | Chung, C. (deposition date: 2020-04-18, release date: 2021-04-14, Last modification date: 2024-05-01) |
Primary citation | Clegg, M.A.,Bamborough, P.,Chung, C.W.,Craggs, P.D.,Gordon, L.,Grandi, P.,Leveridge, M.,Lindon, M.,Liwicki, G.M.,Michon, A.M.,Molnar, J.,Rioja, I.,Soden, P.E.,Theodoulou, N.H.,Werner, T.,Tomkinson, N.C.O.,Prinjha, R.K.,Humphreys, P.G. Application of Atypical Acetyl-lysine Methyl Mimetics in the Development of Selective Inhibitors of the Bromodomain-Containing Protein 7 (BRD7)/Bromodomain-Containing Protein 9 (BRD9) Bromodomains. J.Med.Chem., 63:5816-5840, 2020 Cited by PubMed: 32410449DOI: 10.1021/acs.jmedchem.0c00075 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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