6YOQ

Crystal structure of YTHDC1 with compound VVR_DC1_002

Summary for 6YOQ

• Entry DOI: 10.2210/pdb6yoq/pdb
• Descriptor: YTHDC1, 6-methyl-~{N}-[2-(methylsulfonylamino)ethyl]-2-oxidanylidene-3~{H}-pyridine-3-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: ythdc1, m6a, complex, inhibitor, rna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 43153.38

Authors

von Roten, V.,Bedi, R.K.,Caflisch, A. (deposition date: 2020-04-14, release date: 2020-07-15, Last modification date: 2024-01-24)

• Primary citation: Li, Y.,Bedi, R.K.,Nai, F.,von Roten, V.,Dolbois, A.,Zalesak, F.,Nachawati, R.,Huang, D.,Caflisch, A.; Structure-based design of ligands of the m6A-RNA reader YTHDC1; Eur J Med Chem Rep, 5:100057-, 2022; DOI: 10.1016/j.ejmcr.2022.100057

Experimental method

X-RAY DIFFRACTION (1.3 Å)