6YOJ

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one

6YOJ の概要

• エントリーDOI: 10.2210/pdb6yoj/pdb
• 分子名称: Focal adhesion kinase 1, 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1~{H}-quinolin-2-one (3 entities in total)
• 機能のキーワード: protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32795.71

構造登録者

Musil, D.,Heinrich, T. (登録日: 2020-04-14, 公開日: 2021-02-10, 最終更新日: 2024-01-24)

• 主引用文献: Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S.; Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.; Cell Chem Biol, 28:686-, 2021; PubMed: 33497606; DOI: 10.1016/j.chembiol.2021.01.003

実験手法

X-RAY DIFFRACTION (1.361 Å)