6YJF

Plasmoodium vivax phosphoglycerate kinase bound to nitrofuran inhibitor from PEGSmear at pH 6.5

Summary for 6YJF

• Entry DOI: 10.2210/pdb6yjf/pdb
• Descriptor: Phosphoglycerate kinase, GLYCEROL, (2~{S})-2-(5-nitrofuran-2-yl)-2,3,5,6,7,8-hexahydro-1~{H}-[1]benzothiolo[2,3-d]pyrimidin-4-one, ... (4 entities in total)
• Functional Keywords: phosphoglycerate kinase, metabolic enzyme, kinase, biosynthetic protein
• Biological source: Plasmodium vivax
• Total number of polymer chains: 1
• Total formula weight: 45610.45

Authors

Hyvonen, M.,Brear, P.,Blaszczyk, B.K. (deposition date: 2020-04-03, release date: 2021-04-14, Last modification date: 2024-01-24)

• Primary citation: King, L.,Brear, P.,Bourgard, C.,Cassiano, C.,Mota, D.,Blaszczyk, B.K.,Tomaz, K.,Khedim, M.,Furlan, M.,Ramos, P.,Andresen, E.,Tarczykowska, A.,Tiburcio, L.,Kurowska, A.,Sulskis, D.,Oliver, S.,Grotli, M.,Massirer, K.,Saphire, E.,Burmann, B.,Witkowski, B.,Costa, F.,Sunnerhagen, P.,Hyvonen, M.,Bilsland, E.; Phosphoglycerate Kinase as a potential target for antimalarial therapy; to be published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)