6YIL

Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand

6YIL の概要

• エントリーDOI: 10.2210/pdb6yil/pdb
• 分子名称: CREBBP, (3~{R})-~{N}-[3-(3,4-dihydro-2~{H}-quinolin-1-yl)-2,2-bis(fluoranyl)propyl]-3-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoxaline-5-carboxamide (3 entities in total)
• 機能のキーワード: bromodomain, crebbp, small molecule, benzo-diazepine, sgc, structural genomics consortium, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14637.80

構造登録者

Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. (登録日: 2020-04-01, 公開日: 2020-04-15, 最終更新日: 2024-01-24)

• 主引用文献: Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P.; Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand; To Be Published,

実験手法

X-RAY DIFFRACTION (1.22 Å)