6YIK

Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand

Summary for 6YIK

• Entry DOI: 10.2210/pdb6yik/pdb
• Descriptor: CREBBP, (3~{R})-~{N}-[3-(3,4-dihydro-2~{H}-quinolin-1-yl)-2,2-bis(fluoranyl)propyl]-3-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-quinoxaline-5-carboxamide (3 entities in total)
• Functional Keywords: bromodomain, crebbp, small molecule, benzo-diazepine, sgc, structural genomics consortium, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 44742.29

Authors

Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P. (deposition date: 2020-04-01, release date: 2020-04-15, Last modification date: 2024-01-24)

• Primary citation: Picaud, S.,Brand, M.,Tobias, K.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Conway, S.,Filippakopoulos, P.; Crystal structure of the CREBBP bromodomain in complex with a tetrahydroquinoxaline ligand; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)