6YI8

HUMAN FGFR4 KINASE DOMAIN (447-753) IN COMPLEX WITH ROBLITINIB

6YI8 の概要

• エントリーDOI: 10.2210/pdb6yi8/pdb
• 分子名称: Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: tyrosine kinase inhibitor, covalent reversible inhibitor, fgfr4, roblitinib, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70178.74

構造登録者

Ostermann, N. (登録日: 2020-04-01, 公開日: 2020-09-30, 最終更新日: 2024-01-24)

• 主引用文献: Fairhurst, R.A.,Knoepfel, T.,Buschmann, N.,Leblanc, C.,Mah, R.,Todorov, M.,Nimsgern, P.,Ripoche, S.,Niklaus, M.,Warin, N.,Luu, V.H.,Madoerin, M.,Wirth, J.,Graus-Porta, D.,Weiss, A.,Kiffe, M.,Wartmann, M.,Kinyamu-Akunda, J.,Sterker, D.,Stamm, C.,Adler, F.,Buhles, A.,Schadt, H.,Couttet, P.,Blank, J.,Galuba, I.,Trappe, J.,Voshol, J.,Ostermann, N.,Zou, C.,Berghausen, J.,Del Rio Espinola, A.,Jahnke, W.,Furet, P.; Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.; J.Med.Chem., 63:12542-12573, 2020; PubMed: 32930584; DOI: 10.1021/acs.jmedchem.0c01019

実験手法

X-RAY DIFFRACTION (2.13 Å)