6YHD

tRNA-guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-4-(2-((2R,3S,4R,5R)-3,4-dihydroxy-5-methoxytetrahydrofuran-2-yl)ethyl)-2-(methylamino)-3,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

6YHD の概要

• エントリーDOI: 10.2210/pdb6yhd/pdb
• 関連するPDBエントリー: 6YGZ 6YH2
• 分子名称: Queuine tRNA-ribosyltransferase, methyl 6-[6-amino-2-(methylamino)-8-oxo-7,8-dihydro-1H-imidazo[4,5-g]quinazolin-4-yl]-5,6-dideoxy-beta-D-ribo-hexofuranoside, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: transferase, tgt, trna-guanine transglycosylase, guanine insertion enzyme, homodimer, 19f nmr
• 由来する生物種: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43817.23

構造登録者

Nguyen, A.,Heine, A.,Klebe, G. (登録日: 2020-03-28, 公開日: 2020-04-08, 最終更新日: 2024-01-24)

• 主引用文献: Nguyen, A.,Heine, A.,Klebe, G.; Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts; To Be Published,

実験手法

X-RAY DIFFRACTION (1.25 Å)