6YFZ

Crystal structure of MKK7 (MAP2K7), apo form

6YFZ の概要

• エントリーDOI: 10.2210/pdb6yfz/pdb
• 分子名称: Dual specificity mitogen-activated protein kinase kinase 7 (2 entities in total)
• 機能のキーワード: kinase, kinase inhibitor, mkk7, mek7, map2k7, map2k, mek, jnk signaling, structural genomics, structural genomics consortium, sgc, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34944.62

構造登録者

Chaikuad, A.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2020-03-27, 公開日: 2020-08-12, 最終更新日: 2024-01-24)

• 主引用文献: Schroder, M.,Tan, L.,Wang, J.,Liang, Y.,Gray, N.S.,Knapp, S.,Chaikuad, A.; Catalytic Domain Plasticity of MKK7 Reveals Structural Mechanisms of Allosteric Activation and Diverse Targeting Opportunities.; Cell Chem Biol, 27:1285-1295.e4, 2020; PubMed: 32783966; DOI: 10.1016/j.chembiol.2020.07.014

実験手法

X-RAY DIFFRACTION (1.9 Å)