6YF1

FKBP12 in complex with the BMP potentiator compound 8 at 1.12A resolution

Summary for 6YF1

• Entry DOI: 10.2210/pdb6yf1/pdb
• Related: 6YF0
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, (1aR,3R,5S,6R,7S,9R,10R,17aS,20S,21R,22S,25R,25aR)-25-Ethyl-10,22-dihydroxy-20-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-5,7-dimethoxy-1a,3,9,21-tetramethyloctadecahydro-2H-6,10-epoxyoxireno[p]pyrido[2,1-c][1,4]oxazacyclotricosine-11,12,18,24(1aH,14H)-tetrone (3 entities in total)
• Functional Keywords: immunosuppression, immunosuppressant, bmp enhancer program, isomerase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 12798.68

Authors

Kallen, J. (deposition date: 2020-03-25, release date: 2021-03-10, Last modification date: 2024-01-24)

• Primary citation: Larraufie, M.H.,Gao, X.,Xia, X.,Devine, P.J.,Kallen, J.,Liu, D.,Michaud, G.,Harsch, A.,Savage, N.,Ding, J.,Tan, K.,Mihalic, M.,Roggo, S.,Canham, S.M.,Bushell, S.M.,Krastel, P.,Gao, J.,Izaac, A.,Altinoglu, E.,Lustenberger, P.,Salcius, M.,Harbinski, F.,Williams, E.T.,Zeng, L.,Loureiro, J.,Cong, F.,Fryer, C.J.,Klickstein, L.,Tallarico, J.A.,Jain, R.K.,Rothman, D.M.,Wang, S.; Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury.; Cell Chem Biol, 28:1271-, 2021; PubMed: 33894161; DOI: 10.1016/j.chembiol.2021.04.001

Experimental method

X-RAY DIFFRACTION (1.12 Å)